Table 3.
Parameters | Controls | Tmsbw (daily oral dosage) | ||||
---|---|---|---|---|---|---|
Normal (uninfected) | Negative (untreated) | Positive (chloroquine) | 100 mg/kg | 200 mg/kg | 400 mg/kg | |
RBC (103/mm3) | 6.38 ± 1.97b | 3.72 ± 0.97a | 4.19 ± 0.83a | 4.04 ± 0.61a | 4.52 ± 1.33a | 4.97 ± 1.37a |
HGB (g/dL) | 14.04 ± 1.62a | 8.83 ± 1.50b | 10.51 ± 2.97a | 11.36 ± 0.81a | 14.73 ± 5.64a | 16.32 ± 6.09a |
HCT (%) | 72.92 ± 9.08b | 29.00 ± 6.98a | 33.36 ± 6.27a | 32.37 ± 4.31a | 36.8 ± 4.61a | 37.56 ± 7.14a |
MCV (fL) | 97.33 ± 7.02a | 87.17 ± 10.22a | 86.28 ± 9.64a | 82.45 ± 5.18a | 77.82 ± 10.91a | 82.04 ± 13.29a |
MCH (pg) | 23.52 ± 5.88a | 67.57 ± 18.85b | 46.40 ± 2.25a | 42.46 ± 13.48a | 68.05 ± 10.91b | 30.53 ± 0.57a |
MCHC (g/dL) | 19.22 ± 1.24a | 38.18 ± 3.90b | 34.40 ± 7.19a | 31.95 ± 13.48a | 28.22 ± 2.00a | 31.53 ± 3.12a |
WBC (103/μL) | 11.50 ± 3.30a | 14.30 ± 2.07b | 5.84 ± 2.10a | 21.84 ± 2.07a | 24.75 ± 1.46a | 21.70 ± 3.83a |
LYM (103/mm3) | 10.16 ± 2.83b | 2.05 ± 0.31a | 3.26 ± 0.71a | 4.05 ± 1.34a | 2.49 ± 0.92a | 5.17 ± 1.83a |
MON (%) | 0.75 ± 0.17b | 1.56 ± 0.48a | 1.10 ± 0.32a | 5.16 ± 0.22a | 1.00 ± 0.29a | 2.68 ± 0.75a |
GRA (103/mm3) | 0.93 ± 0.23b | 4.63 ± 0.71a | 6.38 ± 1.91a | 4.84 ± 1.92a | 5.17 ± 0.73a | 4.36 ± 0.73a |
PLT (103/mm3) | 445 ± 109a | 565 ± 123a | 497 ± 91a | 358 ± 127a | 458 ± 114a | 509 ± 160a |
MCHC: mean corpuscular hemoglobin concentration; MCH: mean corpuscular hemoglobin; HCT: hematocrit; HGB: hemoglobin concentration; LYM: lymphocyte; MON: monocyte; GRA: granulocyte; MCV: mean corpuscular volume; RBC: red blood cell; PLT: platelet; WBC: white blood cell; Tm: Terminalia mantaly; sb: stem bark. wWater. a, bStatistical difference at P < 0.05 (n = 5); the same letters on the same line indicate no statistical differences. Obtained data were compared as follows: negative control with normal group and infected treated groups with negative control.