IVT ADVM-022 Provides Levels of Intraocular Aflibercept Expression Comparable with Those Measured 21–32 Days following IVT Injection of Aflibercept Recombinant Protein (n = 4 Eyes, 2 Animals for Each Data Point)
(A) Vitreous humor. (B) Aqueous humor. (C) Retina. (D) Choroid. The dotted lines indicate the times on the decay curves when recombinant aflibercept levels are equivalent to those seen in the ADVM-022-treated groups’ low (2 × 1011 vg/eye, purple), middle (6 × 1011 vg/eye, green), and high (2 × 1012 vg/eye, red) doses tested on day 56. Error bars represent standard deviations.