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Teicoplanin initial trough concentration (Cmin) in patients receiving a conventional or enhanced high loading dose regimen
| Initial Cmin (μg/mL) | Conventional high loading dose regimen (n = 363) | Enhanced high loading dose regimen (n = 149) | P-value |
|---|---|---|---|
| Median (interquartile range) | 18.3 (15.1–22.8) | 24.9 (20.8–28.3) | < 0.001 |
| No. of patient according to the Cmin categories (%) | |||
| < 20 | 213 (58.7%) | 32 (21.5%) | < 0.001 |
| 20–40 | 149 (41.0%) | 112 (75.2%) | < 0.001 |
| ≥ 40 | 1 (0.3%) | 5 (3.4%) | 0.009 |
