Table 2.
Associations Between Predictor Variables of interest With Square-Root Transformed Serum Soluble α-Klotho
| Univariable Models | Multivariable Models | |||||||
|---|---|---|---|---|---|---|---|---|
| Predictor Variable | N | β | 95% CI | P value | N | β | 95% CI | P value |
| Age, y | 912 | -0.0038 | -0.0068 to -0.0007 | .015 | 905 | -0.0009 | -0.00560 to .0038 | .70 |
| Sex, women | 912 | 0.1507 | 0.0484–0.2534 | .0035 | 905 | 0.1620 | 0.0586–0.2669 | .0021 |
| BMI, kg/m2 | 911 | -0.0172 | -0.0303 to -0.0041 | .010 | 905 | -0.0084 | -0.022 to 0.0051 | .22 |
| eGFRcr, mL/min per 1.73 m2 BSA | 906 | 0.0044 | 0.0013–0.0075 | .0051 | 905 | 0.0024 | -0.0022 to 0.007 | .31 |
| PTH, pg/mL | 909 | -0.0032 | -0.0074 to 0.001 | .13 | 902 | 0.0063 | 0.0001–0.0125 | .049 |
| Interaction with sex | -0.0111 | -0.0188 to -0.0035 | .0045 | |||||
| Sex, women in the model | 0.1697 | 0.2814–0.9137 | .00129 | |||||
| 25-OH-vitamin D, nmol/L | 908 | 0.0022 | -0.0004 to 0.0049 | .099 | 901 | 0.0014 | -0.0013 to 0.004 | .32 |
| 1,25-(OH)2 vitamin D3, pmol/L | 846 | 0.0000 | -0.0017 to 0.0018 | .99 | 840 | -0.0006 | -0.0023 to 0.0012 | .55 |
| FGF23, RU/mL | 912 | 0.0001 | -0.0005 to 0.0008 | .69 | 905 | 0.0002 | -0.0005 to 0.0008 | .64 |
| Phosphate plasma, mmol/L | 904 | 0.0702 | -0.2671 to 0.4056 | .68 | 903 | -0.0648 | -0.4120 to 0.2797 | .71 |
| Interaction with age | -0.0220 | -0.0387 to -0.0050 | .011 | |||||
| Age in the model | -0.0007 | -0.0054 to 0.0040 | .76 | |||||
| Calcium, mmol/L | 905 | 0.6672 | 0.0265–1.3091 | .042 | 904 | 0.3957 | -0.2358 to 1.0263 | .22 |
| Phosphate urine, mmol/24 h | 890 | -0.0035 | -0.009 to 0.002 | .21 | 883 | -0.0005 | -0.0067 to 0.0057 | .87 |
| Fractional excretion of phosphate, % | 881 | -0.0030 | -0.0146 to 0.0086 | .61 | 880 | 0.0053 | -0.008 to 0.0186 | .44 |
| TmP/GFR, mmol/L | 881 | 0.1165 | -0.1643 to 0.3957 | .41 | 880 | -0.0468 | -0.3531 to 0.2571 | .76 |
| Calcium urine, mmol/24 h | 887 | -0.0173 | -0.0434 to 0.0086 | .19 | 880 | -0.0068 | -0.0326 to 0.019 | .61 |
| Fractional excretion of calcium, % | 876 | -0.0294 | -0.0564 to 0.0482 | .31 | 875 | -0.0123 | -0.0544 to 0.0463 | .66 |
For each predictor variable, the results of an univariable and of a multivariable model are shown. Number of participants (N), beta coefficients (β), 95% confidence intervals (95% CI), and P values are indicated for the predictor variables of interest and in multivariable models also for significant interactions.
Abbreviations: eGFRcr, glomerular filtration rate estimated creatinine equation CKD-EPI 2009; TmP/GFR, tubular maximum reabsorption of phosphorus per glomerular filtration rate.