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. Author manuscript; available in PMC: 2020 Jul 8.
Published in final edited form as: Chem Res Toxicol. 2019 Nov 11;32(12):2433–2444. doi: 10.1021/acs.chemrestox.9b00228

Figure 5.

Figure 5.

Inhibitory effects of DTCs and anti-cancer drugs on neurite outgrowth. Neurite length is measured by maximum length method. The number of cells are counted as object number according to the shape of cell body. Neurons treated with DTCs and anti-cancer drugs for 24 h showed inhibition of neurite outgrowth. (A) Representative images of ferbam and thiram induced-neurite outgrowth inhibition. (B) Differential inhibitory effects of DTCs in neurite outgrowth and object number. Dialkyl dithiocarbamates with different metal ions, and tetra-alkyl thiuram disulfide with different R-group were compared separately. (C) Representative images of anti-cancer drugs-induced neurite outgrowth inhibition. (D) Differential inhibitory effects of anti-cancer drugs in neurite outgrowth assay and object number. Data from (B) and (D) are expressed as mean ± SD from three experiments.