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. Author manuscript; available in PMC: 2020 Jul 8.
Published in final edited form as: Chem Res Toxicol. 2019 Nov 11;32(12):2433–2444. doi: 10.1021/acs.chemrestox.9b00228

Table 2.

Outcomes of dimethyldithiocarbamates complexed with different metals in SBE-bla, WNT-, RAR-, SHH-luc assays.

Sample Name CASRN Structure SBE Antagonist WNT Antagonist RAR Antagonist SHH Antagonist
IC50 (μM) Efficacy (%) IC50 (μM) Efficacy (%) IC50 (μM) Efficacy (%) IC50 (μM) Efficacy (%)
Ferbam 14484-64-1 graphic file with name nihms-1573862-t0002.jpg 0.05 −80.99 0.57 −66.42 0.83 −93.29 0.05 −87.88
Ziram 137-30-4 graphic file with name nihms-1573862-t0003.jpg 0.52 −93.60 0.85 −81.79 1.39 −106.31 0.42 −92.50
Sodium dimethyldithiocarbamate 128-04-1 graphic file with name nihms-1573862-t0004.jpg 9.14 −68.19 Inactive Inactive 17.37 −93.31 6.73 −87.30

Potency (IC50) and efficacy (activity %) in inhibiting TGFβ WNT, RAR, and SHH pathways by ferbam, ziram, and sodium dimethyldithiocarbamates were compared in the table.