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. Author manuscript; available in PMC: 2020 Jul 8.
Published in final edited form as: Chem Res Toxicol. 2019 Nov 11;32(12):2433–2444. doi: 10.1021/acs.chemrestox.9b00228

Table 3.

Outcomes of Na-DTCs with different size of alkyl group in SBE-bla, WNT-, RAR-, SHH-luc assays.

Sample Name CASRN Structure SBE Antagonist WNT Antagonist RAR Antagonist SHH Antagonist
IC50 (μM) Efficacy (%) IC50 (μM) Efficacy (%) IC50 (μM) Efficacy (%) IC50 (μM) Efficacy (%)
Sodium dimethyldithiocarbamate 128-04-1 graphic file with name nihms-1573862-t0005.jpg 9.14 −68.19 Inactive Inactive 17.37 −93.31 6.73 −87.30
Sodium diethyldithiocarbamate 148-18-5 graphic file with name nihms-1573862-t0006.jpg 11.49 −58.53 3.69 −74.76 15.31 −113.16 8.92 −96.63
Sodium dibutylcarbamodithioate 136-30-1 graphic file with name nihms-1573862-t0007.jpg Inactive Inactive Inactive Inactive Inactive Inactive Inactive Inactive

Potency (IC50) and efficacy (activity %) in inhibiting TGFβ WNT, RAR, and SHH pathways by sodium dimethyl-, diethyl-, and dibutyl- dithiocarbamates were compared in the table.