Figure 3.

Maturity of the microbiome in GH-/- (blue) and bGH mice (red) compared with respective littermate controls (gray). A. Maturity in the GH-/- microbiome compared with controls. GH-/- mice have a significant decrease with a very large effect size in age maturity between the expected microbial community and the actual microbial community (Cohen d effect size = 1.45). *P = 0.043, Mann Whitney U test. B. Maturity in the bGH microbiome compared with controls. bGH mice have a slight increase in maturity compared with littermate controls, but this finding is nonsignificant with a large effect size (Cohen d effect size = 0.79).