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. 2020 Feb 26;161(4):bqaa026. doi: 10.1210/endocr/bqaa026

Figure 6.

Figure 6.

Intestinal gross anatomy and histology in 6 month or 12 month old GH-/- mice compared (blue) to littermate controls (gray). A. Intestinal length of the small and large intestines (6 months). *P < 0.001 (Cohen d = 3.11). B. Intestinal weight of the small and large intestines (6 months). *P < 0.001 (Cohen d = 3.06 and 2.48, respectively). C. Intestinal circumference of the jejunum (SI) and colon (LI) in 12-month-old GH-/- mice compared with controls. *P = 0.01 and 0.03 (Cohen d = 4.05 and 3.33, respectively). D-F. Duodenum, jejunum and ileum morphology, respectively, including villus height, crypt depth, and muscle thickness of 12-month-old mice. D. GH-/- mice had significantly decreased villus height in duodenum. *P = 0.028 (Cohen d = 2.73). E. GH-/- had significantly decreased villus height in jejunum. *P = 0.049 (Cohen d = 2.08). G. Colon morphology in 12-month-old GH-/- mice compared to controls. H-K: Small intestinal histology in 12-month-old GH-/- mice and controls. H. Control jejunum. I. GH-/- jejunum. J. Control ileum. K. GH-/- Ileum.