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. 2020 Jul 7;18:103. doi: 10.1186/s12964-020-00580-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Relationship between p53-KD and cancer stem cell features or cell migration. a Aldefluor analysis in OV-shp53 and control cells. Note the R1 populations including the ALDH^high population with cancer stem cell-like features. b Left: wound-healing assay with OV-shp53 and control cells. A scratch ‘wound’ was introduced to the middle of wells containing cell growth to confluency, and phase contrast images were taken after 6, 9, and 12 h. Right: the values of wound areas in 0 h were set as 1. The fold wound areas are presented as means±SDs. C, control. c Migration rate measured using transwell assay. Left: the OV-shp53 and control cells were seeded in a 24-well transwell plates and incubated for 24 h in medium without serum. Cells were stained with HE and counted using a light microscope. Right: the numbers of migrated cells are presented as means±SDs