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. 2020 Jun;16(2):200001. doi: 10.1183/20734735.0001-2020

Figure 1.

Figure 1

Pathways of surfactant processing. TTF1 is the transcription factor regulating SP-B and SP-C synthesis; ABCA3 is crucial for post-translational, intracellular surfactant processing; granulocyte–macrophage colony-stimulating factor (GM-CSF) regulates surfactant catabolism. The mucociliary escalator is not clinically important in surfactant clearance.