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. 2020 Jul 8;26:68. doi: 10.1186/s10020-020-00187-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — WRN overexpression inhibits ATM/p53 signaling pathway. SRA01/04 cells were transfected with pcDNA3.1-WRN or pcDNA3.1-NC, and then the modified SRA01/04 cells were treated with 100 μM H₂O₂. a WB was performed to detect the expression of p-ATM, ATM, p53, p-p53, p21, Bax, PUMA and NOXA in the modified SRA01/04 cells. SRA01/04 cells were consecutively treated with 100 μM H₂O₂ and 5-Aza-CdR. b WB was performed to estimate the expression of p-ATM, ATM, p53, p-p53, p21, Bax, PUMA and NOXA in the modified SRA01/04 cells.(^**P < 0.01 compared with the Control group, ^##P < 0.01 compared with the H₂O₂ + Vector group, ^$P < 0.05 compared with the H₂O₂ group, ^$$P < 0.01 compared with the H₂O₂ group)