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. 2020 Jul 7;11:3383. doi: 10.1038/s41467-020-17205-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Workflow of the experimental approach. b H3K27ac marks and BRD4 binding sites strongly correlate in both SHAM and IRI samples. c Broad peak calling was applied on H3K27ac SHAM and IRI samples. 29,925 peaks overlapped between them; 7439 and 11,406 were only identified in SHAM or IRI samples, respectively. d 56% of the identified peaks SHARED between both samples are enhancer elements, whereas 44% are promoter elements. Peaks identified with preferential binding in SHAM samples (IRI-decreased) consist of 88% enhancers and 12% promoter regions. Out of 11,406 peaks identified with preferential binding in IRI samples (IRI-increased) 86% are enhancers and 14% are promoters.