Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 7;11:3383. doi: 10.1038/s41467-020-17205-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — a C57BL/6N mice (10- to 12-week-old males) were treated daily starting at the day of SHAM or IRI surgery (d0) with JQ1 (50 mg/kg BW) or vehicle (DMSO/10% ß-cyclo dextrin 1:10). b Serum creatinine (mg/dL) values in SHAM and IRI animals with vehicle or JQ1 at day 1 after surgery are shown (individual data points and mean ± SD). SHAM: n = 4; IRI: n = 12 biologically independent samples. c Survival curves after IRI surgery (ischemic time was 26 min at 37 °C). JQ1 treatment leads to 80% mortality after IRI surgery. Table shows number of animals alive at indicated days. d Experimental design of delayed treatment with JQ1 (50 mg/kg BW) after IRI starting at day 1, day 2, day 3 or day 4. e Serum creatinine levels at day 1 after IRI, verifying that AKI was induced to a roughly equivalent extent in each of the groups of animals that were subsequently treated with JQ1 (individual data points and mean ± SD). IRI veh: n = 11; IRI d1: n = 12; IRI d2: n = 8; IRI d3: n = 9; IRI d4: n = 7 biologically independent samples. f Survival curve after delayed JQ1 treatment starting day 1, day 2, day 3 or day 4. Table indicates number of animals alive at each day. Box indicates start of vehicle or JQ1 treatment. Source data are provided as a Source data file.