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. 2020 Jul 7;4:20. doi: 10.1038/s41698-020-0125-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Heatmap of the expression data of 2000 differentially expressed genes among four clusters (NL and three hepatoblastoma clusters F, E1, and E2; Supplementary Data S8) across 35 hepatoblastoma biopsy samples and ten NL samples. The expression level is log-transformed and z-normalized to zero mean and unit standard deviation for each gene. b Principal component analysis plot for the expression data. Summarized results of the pathway analysis of differential expression among the hepatoblastoma and NL clusters are added on the plot; a black arrow directed from cluster X to Y and pathway A described nearby with an upward/downward arrow indicates significant upregulation/downregulation of pathway A in cluster Y compared with cluster X.