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. 2020 Jul 7;10:11148. doi: 10.1038/s41598-020-67594-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third-party material in this article is included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Altered testis development of Slc16a2−/− rat. (A) Representative images of Slc16a2+/+ and Slc16a2−/− rats at p21. (B) Testis weights of Slc16a2+/+ and Slc16a2−/− rats at p21. n = 6 for each genotypes. (C) Representative images of H&E stained sections of Slc16a2+/+ and Slc16a2−/− rats at p21. (D) Diameter of seminiferous tubules of Slc16a2+/+ and Slc16a2−/− rats at p21 n = 4 for each genotypes. (E) Representative image of Slc16a2+/+ and Slc16a2−/− rats at p49. (F) Testis weights of Slc16a2+/+ and Slc16a2−/− rats at p49. n = 7 for Slc16a2+/+ and n = 5 for Slc16a2−/−. (G) Representative images of H&E stained testis sections of Slc16a2+/+ and Slc16a2−/− rats at p49. (H) Diameter of seminiferous tubules of Slc16a2+/+ and Slc16a2−/− rats at p49. n = 4 for each genotypes. (I) Serum testosterone levels of Slc16a2+/+ and Slc16a2−/− male rats at p49. n = 6 for Slc16a2+/+ and n = 9 for Slc16a2−/−, P < 0.01;**, P < 0.001;*** P < 0.0001;****.