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. 2020 Jul 7;11:3390. doi: 10.1038/s41467-020-17095-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Bar plot showing the percentage of cases with productive IGH rearrangements by IgCaller in each cohort. b Dot plots of the percentage of identity of the rearranged IGHV sequence to the germ line by IgCaller (y axis) and SSeq/NGS (x axis). The 95% confidence interval is depicted by the light blue area. The gray area highlights cases in which the presence of a high density of clustered mutations impairs an accurate identification of the percentage of identity. P values are from t-test. c Comparison of the number of mutations associated with signature 9 (SBS9, left y axis) and the identity of the rearranged sequence both by SSeq and IgCaller (right y axis) in the C1-CLL cohort. Source data are provided as a Source data file.