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. 2020 Jul 7;10:220. doi: 10.1038/s41398-020-00909-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Whole-brain multiple regression showed a negative correlation between PSP and PAG (far left in green) connectivity with the precentral gyrus (PrCG), postcentral gyrus (PoCG), and paracentral lobule (PCL) (right, blue). b AUDIT scores were positively correlated with PSP scores (left) and negatively correlated with averaged connectivity strength of PAG with PrCG, PoCG, and PCL (right). c Mediation analysis showed two significant models in which PSP bidirectionally mediated the negative relationship between PAG connectivity and AUDIT scores. NB: all partial correlations in this and other figures show regression residuals of parameter estimates of connectivity, PSP, and AUDIT scores after the effects of age and sex had been removed. **p < 0.01.