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. 2020 Jul 7;10:220. doi: 10.1038/s41398-020-00909-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a PSP scores were negatively correlated with PAG rsFC (blue) but positively correlated with mOFC rsFC (red) and the two connectivity maps overlapped in the left PrCG (yellow). b PSP scores were negatively predicted by the difference in connectivity strength between PAG/PrCG and mOFC/PrCG, indicating the stronger the PAG/PrCG relative to mOFC/PrCG connectivity, the lower PSP expectancy. c Path analysis showed PAG and mOFC rsFC with the PrCG indirectly and antagonistically influenced drinking severity through their modulation of expectancy. PAG/PrCG rsFC lessened drinking severity by reducing PSP expectancy (blue arrow). In contrast, mOFC/PrCG rsFC exacerbated drinking severity by enhancing PSP expectancy (red arrow). β’s represent path coefficients. **p < 0.01.