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. 2020 Jul 7;10:220. doi: 10.1038/s41398-020-00909-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a During the ACR task, alcohol relative to neutral cues elicited activations in the mOFC, superior frontal gyrus (SFG), and a cluster containing the bilateral occipital cortices (OC) and posterior cingulate cortex (PCC) (red). The reverse contrast showed significant activation in the parieto-occipital sulcus (blue). b PSP scores were negatively correlated with the difference in connectivity strength between PAG/OC and mOFC/OC during alcohol cue processing, indicating the stronger the PAG/OC relative to mOFC/OC connectivity, the lower the PSP expectancy. c Path analysis showed a significant model in which PAG vs. mOFC connectivity strength difference indirectly reduced problem drinking by lowering PSP, which in turn lowered alcohol craving. Solid and dotted lines show significant and non-significant paths, respectively. *p < 0.05, **p < 0.01.