Table 2.
Sensitivity and specificity of BIS by 6 and 24 months for lymphoedema diagnosis (RAVI > 10% and sleeve application).
| No lymphoedema (RAVI < 10%) | Lymphoedema (RAVI > 10%) | Total number | No clinical sleeve | Clinical sleeve | Total number | |
|---|---|---|---|---|---|---|
| By 6 months | ||||||
| BIS (<10) |
698 (82%) Specificity |
27 (31%) PPV |
725 | 690 (80%) | 34 (46%) | 724 |
| BIS (≥10) |
153 (18%) NPV |
59 (69%) Sensitivity |
212 | 170 (20%) | 40 (54%) | 210 |
| RAVI < 10% | – | – | – | 820 (94%) | 45 (60%) | 865 |
| RAVI > 10% | – | – | – | 55 (6%) | 30 (40%) | 85 |
| After 6 months up to 24 months | ||||||
| BIS ( < 10) | 572 (79%) | 32 (32%) | 604 | 556 (80%) | 65 (49%) | 621 |
| BIS ( ≥ 10) | 150 (21%) | 68 (68%) | 218 | 136 (20%) | 69 (51%) | 205 |
| RAVI < 10% | – | – | – | 667 (94%) | 86 (61%) | 753 |
| RAVI > 10% | – | – | – | 39 (6%) | 55 (39%) | 94 |
BIS > 10 increase at 24 months l-Dex sensitivity (68%, 95% CI: 60–75%), and specificity 79%, 95% CI: 77–82% for lymphoedema at 24 months PPV (31%, 95% CI:26–37%) compared to RAVI > 10%