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. 2020 Jul 7;11:3384. doi: 10.1038/s41467-020-17153-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Tissue histology (n = 2) stained with hematoxylin and eosin for major organs of septic mice with the most severe hypothermia at 24 h post CLP in different groups. Histopathological findings: Lung: alveolar congestion (black circle), hemorrhage (blue circle), alveolar thickening, and hyaline membrane formation (arrow); Heart: intracellular edema and contraction bands (arrow), indicating early cell death; Liver: predominantly macrovascular steatosis (blue arrow) and nuclear inclusion (black arrow); Kidney: proximal tubular edema and vacuolization (blue arrow), luminal epithelial desquamation (black arrow), and epithelial nuclear enlargement (circle); Intestine: villous shortening, villous edema, villous necrosis (blue arrow), and loss of goblet cells (green arrow). b The heatmap of multiple inflammatory cytokine profiles, and c quantitative analysis of key cytokines (IL-6, TNF-α, IL-1β, and MCP-1) in both plasma and peritoneal lavage fluids in mice at 24 h post CLP in different treatment groups in comparison with sham mice (n = 4, mean ± SEM. Statistical significance was measured by unpaired one-sided Student’s test). Source data are available in the Source Data file.