TABLE 2: Genotypic, allelic, and carrier frequencies for ACE I/D (rs4646994) polymorphism. Logistic regression results comparing Chagas disease patients of Group B1 with Group A.
| Group B1 | Group A | Odds Ratio | 95% CI | P value | Odds Ratioa | 95% CIa | P valuea | |
|---|---|---|---|---|---|---|---|---|
| N = 144 | N = 100 | |||||||
| (control) | (control) | |||||||
| II | 30 (0.21) | 26 (0.26) | - Reference - | |||||
| DI | 68 (0.47) | 43 (0.43) | 1.37 | 0.72 - 2.62 | 0.34 | 1.06 | 0.51 - 2.42 | 0.80 |
| DD | 46 (0.32) | 31 (0.31) | 1.29 | 0.64 - 2.58 | 0.48 | 1.11 | 0.51 - 2.20 | 0.87 |
| I Allele | 128 (0.44) | 95 (0.48) | - Reference - | |||||
| D Allele | 160 (0.56) | 105 (0.52) | 1.13 | 0.68 - 1.89 | 0.64 | 1.06 | 0.60 - 1.86 | 0.85 |
| D Carriers | 114 (0.79) | 74 (0.74) | 1.34 | 0.73 - 2.44 | 0.35 | 1.08 | 0.55 - 2.12 | 0.82 |
Results are presented as N (frequency). Overall P value for genotype ANOVA= 0.63. aOR values are corrected for the nongenetic variables sex, age, and the use of trypanocidal treatment. n: number of patients; CI: confidence interval.