TABLE 3: Genotypic, allelic, and carrier frequencies for ACE I/D (rs4646994) polymorphism. Logistic regression results comparing Chagas disease patients in Group C with those in Group A.
| Group C | Group A | Odds Ratio | 95% CI | P value | Odds Ratioa | 95% CIa | P valuea | |
|---|---|---|---|---|---|---|---|---|
| N = 99 | N = 100 | |||||||
| (case) | (control) | |||||||
| II | 12 (0.12) | 26 (0.26) | - Reference - | |||||
| DI | 50 (0.51) | 43 (0.43) | 2.52 | 1.13 - 5.59 | 0.02 | 2.02 | 0.88 - 4.70 | 0.10 |
| DD | 37 (0.37) | 31 (0.31) | 2.59 | 1.12 - 5.95 | 0.02 | 2.32 | 0.96 - 5.60 | 0.06 |
| I Allele | 74 (0.37) | 95 (0.48) | - Reference - | |||||
| D Allele | 124 (0.63) | 105 (0.52) | 1.52 | 0.86 - 2.67 | 0.15 | 1.06 | 0.60 - 1.86 | 0.85 |
| D Carriers | 87 (0.88) | 74 (0.74) | 2.55 | 1.20 - 5.40 | 0.02 | 2.15 | 0.97 - 4.73 | 0.06 |
Results are presented as N (frequency). Overall P value for genotype ANOVA = 0.04. aOR values are corrected for the nongenetic variables sex, age, and the use of trypanocidal treatment. CI: confidence interval.