TABLE 4: Genotypic, allelic and carrier frequencies for ACE I/D (rs4646994) polymorphism. Logistic regression results, comparing Chagas disease patients in Group C with those in Group B1.
| Group C | Group B1 | Odds Ratio | 95% CI | P value | Odds Ratioa | 95% CIa | P valuea | |
|---|---|---|---|---|---|---|---|---|
| N = 99 | N = 144 | |||||||
| (case) | (control) | |||||||
| II | 12 (0.12) | 30 (0.21) | - Reference - | |||||
| DI | 50 (0.51) | 68 (0.47) | 1.84 | 0.86 - 3.94 | 0.12 | 1.78 | 0.82 - 3.87 | 0.14 |
| DD | 37 (0.37) | 46 (0.32) | 2.01 | 0.91 - 4.46 | 0.09 | 1.95 | 0.87 - 4.37 | 0.11 |
| I Allele | 74 (0.37) | 128 (0.44) | - Reference - | |||||
| D Allele | 124 (0.63) | 160 (0.56) | 1.34 | 0.79 - 2.26 | 0.27 | 1.32 | 0.78 - 2.24 | 0.30 |
| D Carriers | 87 (0.88) | 114 (0.79) | 1.90 | 0.92 - 3.94 | 0.08 | 1.85 | 0.89 - 3.86 | 0.10 |
Results are presented as N (frequency). Overall P-value for genotype ANOVA= 0.19. aOR values are corrected for the nongenetic variables, sex, age, and the use of trypanocidal treatment. CI: confidence interval.