TABLE 5: Genotypic, allelic, and carrier frequencies for ACE I/D (rs4646994) polymorphism. Logistic regression results comparing Chagas disease patients of Group C with the combined groups; A and B1.
| Group C | Group A + B1 | Odds Ratio | 95% CI | P value | Odds Ratioa | 95% CIa | P valuea | |
|---|---|---|---|---|---|---|---|---|
| N = 99 | N = 244 | |||||||
| (case) | (control) | |||||||
| II | 12 (0.12) | 56 (0.23) | - Reference - | |||||
| DI | 50 (0.51) | 111 (0.45) | 2.10 | 1.03 - 4.26 | 0.04 | 1.94 | 0.95 - 3.98 | 0.07 |
| DD | 37 (0.37) | 77 (0.32) | 2.24 | 1.07 - 4.68 | 0.03 | 2.09 | 0.99 - 4.40 | 0.05 |
| I Allele | 74 (0.37) | 223 (0.46) | - Reference - | |||||
| D Allele | 124 (0.63) | 265 (0.54) | 1.41 | 0.87 - 2.28 | 0.16 | 1.36 | 0.84 - 2.21 | 0.21 |
| D Carriers | 87 (0.88) | 188 (0.77) | 2.16 | 1.10 - 4.23 | 0.02 | 2.00 | 1.01 - 3.96 | 0.04 |
Results are presented as N (frequency). Overall P-value for genotype ANOVA = 0.06. aOR values are corrected for the nongenetic variables, sex, age, and the use of trypanocidal treatment. CI: confidence interval.