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. 2020 Jul 7;10:11134. doi: 10.1038/s41598-020-68058-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Concentration of endocannabinoids and related NAEs in plasma. AEA (a), PEA (b), OEA (c), 2-AG (d) in patients who developed normal scars (N, n = 40) and patients who developed hypertrophic scars (HT, n = 10). Samples were collected immediately before surgery (t0), 5 days after surgery (t5d), 12 days after surgery (t12d) and 3 months after surgery (t3m). Four plasma samples for each patient were collected at different times. *p < 0.05 comparing t0 values in the control group; Φ p < 0.05 comparing t5d values. Θ Comparing t12d values (Tukey’s multiple comparison test).