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. 2020 Jul 7;10:11134. doi: 10.1038/s41598-020-68058-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Concentration of endocannabinoids and related NAEs in plasma and skin. Relationship between the concentrations of AEA in (a) normal scars and (b) hypertrophic scars; PEA in (c) normal scars and (d) hypertrophic scars; OEA in (e) normal scars and (f) hypertrophic scars; and 2-AG in (g) normal scars and (h) hypertrophic scars in the plasma and skin of patients who developed normal and hypertrophic scars. A positive correlation with a Pearson r of 0.38 (p = 0.0152) with a linear regression slope of 0.44 ± 0.17, including a 95% confidence limit, was found for AEA in patients who developed normal scars (a). No significant correlation was found for AEA in patients who developed HT scars (b). No significant correlation was found for PEA (c, d), OEA (e, f), and 2-AG (g, h) in either group of patients.