Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 7;11:3394. doi: 10.1038/s41467-020-17110-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a, c Upper: representative raw Per2::Luciferase PMT traces of Cry1-null SCN before (black) and during (green) initiation of conditional Cry1-expression, and following AAV washout (WO) (coloured by genotype: VIP^Cre (blue), VPAC2^Cre (pink) and VIP^Cre;VPAC2^Cre (purple)). Lower: corresponding peak-to-peak period plots (mean ± SEM) for VIP^Cre, VPAC2^Cre and VIP^Cre;VPAC2^Cre SCN. Arrow indicates addition of conditional Cry1 AAV. For peak-to-peak period plots, joined grey points represent individual slices; coloured points represent mean ± SEM with colours denoting treatment interval in traces as above. d Summary period data for: pre-AAV-Cry1 baseline (black) and post-AAV-Cry1 washout for VIP^Cre (blue), VPAC2^Cre (pink) and VIP^Cre;VPAC2^Cre (purple) SCN (**p = 0.007, ****p < 0.0001). Histograms: paired points represent individual slices; bars represent mean ± SEM (n = 7, 9 and 10 for VIP^Cre, VPAC2^Cre and VIP^Cre;VPAC2^Cre). Statistics: d repeated-measures two-way ANOVA with Sidak’s correction for multiple comparisons. Only significant comparisons (p < 0.05) are shown. Source data are provided as a source data file.