Table 2.
Mean and SD of metabolites, ADC, rCBV and rCBF of the diseased and the contralateral healthy side <27 weeks and >52 weeks after stereotactic radiosurgery (SRS).
| Variable | <27 weeks | Diseased n = 11 Mean ± SD | Contralateral Mean ± SD | P-value adjusted | >52 weeks | Diseased n = 11 Mean ± SD | Contralateral Mean ± SD | P-value adjusted | |
|---|---|---|---|---|---|---|---|---|---|
| 1H-MRSI | |||||||||
| Cho | |||||||||
| Center | 1.43 ± 0.61 | 1.32 ± 0.42 | 1 | 1.24 ± 0.38 | 1.00 ± 0.21 | 0.72 | |||
| 1st ring | 1.78 ± 1.00 | 1.38 ± 0.51 | 0.948 | 1.31 ± 0.34 | 1.02 ± 0.35 | <0.001 | |||
| 2nd ring | 1.73 ± 0.95 | 1.54 ± 0.53 | 1 | 1.33 ± 0.36 | 0.96 ± 0.43 | 0.004 | |||
| NAA | |||||||||
| Center | 2.98 ± 1.70 | 7.03 ± 2.81 | 0.015 | 1.63 ± 1.28 | 5.43 ± 1.88 | 0.002 | |||
| 1st ring | 3.74 ± 1.40 | 7.02 ± 3.26 | 0.106 | 2.87 ± 1.80 | 5.26 ± 1.33 | 0.01 | |||
| 2nd ring | 5.18 ± 1.77 | 6.48 ± 4.76 | 0.858 | 3.78 ± 1.50 | 5.01 ± 1.67 | 0.043 | |||
| Cr | |||||||||
| Center | 3.72 ± 1.42 | 5.51 ± 1.73 | 0.19 | 3.29 ± 1.57 | 3.88 ± 0.88 | 1 | |||
| 1st ring | 5.07 ± 1.09 | 5.40 ± 1.34 | 1 | 4.06 ± 1.28 | 4.12 ± 1.61 | 1 | |||
| 2nd ring | 5.90 ± 2.18 | 5.25 ± 1.63 | 1 | 4.55 ± 1.38 | 4.32 ± 1.64 | 1 | |||
| Lac | |||||||||
| Center | 3.37 ± 2.70 | 0.27 ± 0.35 | 0.026 | 1.52 ± 1.75 | 0.45 ± 0.59 | 0.193 | |||
| 1st ring | 2.34 ± 2.37 | 0.20 ± 0.23 | 0.115 | 1.24 ± 0.38 | 1.00 ± 0.21 | 0.013 | |||
| 2nd ring | 1.30 ± 2.15 | 0.18 ± 0.26 | 0.72 | 1.31 ± 0.34 | 1.02 ± 0.35 | 0.11 | |||
| DWI | |||||||||
| ADC | |||||||||
| lesion | 122.50 ± 24.62 | 76.10 ± 8.27 | <0.001 | 129.04 ± 33.02 | 72.39 ± 7.49 | <0.001 | |||
| adjacent | 126.39 ± 28.59 | 75.80 ± 7.36 | <0.001 | 137.67 ± 51.69 | 72.52 ± 13.82 | <0.001 | |||
| PWI | |||||||||
| CBV | |||||||||
| lesion | 338.88 ± 174.85 | 197.11 ± 159.99 | <0.001 | 455.01 ± 203.77 | 150.00 ± 151.00 | 0.003 | |||
| c-e rim | 523.11 ± 393.38 | 197.11 ± 159.99 | <0.001 | 589.84 ± 167.32 | 150.00 ± 151.00 | <0.001 | |||
| adjacent | 226.33 ± 159.34 | 300.55 ± 209.56 | 1 | 191.32 ± 169.09 | 219.09 ± 151.02 | 1 | |||
| CBF | |||||||||
| Lesion | 53.00 ± 29.51 | 39.60 ± 16.52 | 0.221 | 99.65 ± 63.33 | 60.87 ± 35.09 | 0.72 | |||
| c-e rim | 157.00 ± 96.14 | 39.60 ± 16.52 | 0.009 | 1 35.65 ± 83.86 | 60.87 ± 35.09 | 0.12 | |||
| adjacent | 91.33 ± 99.10 | 85.44 ± 88.08 | 1 | 31.70 ± 12.27 | 35.45 ± 22.76 | 1 | |||
P-values below 0.05 are boldfaced.
Lesion former target of SRS, c-e rim contrast-enhancing rim of the lesion, Adjacent brain parenchyma adjacent to the borders of SRS.