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. 2020 Jul 7;10:11143. doi: 10.1038/s41598-020-68113-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hepatic gene expression in the liver of Gprc6a-^KGKY-knockin mice. (A and B) Volcano plot (a); Heat map (b) of regulated genes between WT and Gprc6a-^KGKY-knockin mice. Blue and red colors indicate high and low gene expression, respectively. Volcano plot and heat map visualization of the hepatic transcriptome demonstrated distinct differences between WT and Gprc6a-^KGKY-knockin mice. (c–e) Gene ontology (c), the Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) (d) and Mammalian phenotype (e) in the liver of Gprc6a-^KGKY-knockin mice. The top rank ordered processes, maps and networks are based on statistical significance.