Table 4.
Hazard ratios (HR) with 95% confidence intervals (CI) of mortality comparing patients with hepatocellular carcinoma undergoing surgical resection in Oulu University Hospital 1983–2018.
| Negative budding (n = 23) HR (95% CI) | Positive budding (n = 24) HR (95% CI) | P value | High TSR (n = 34) HR (95% CI) | Low TSR HR (95% CI) | P value | |
|---|---|---|---|---|---|---|
| 5-year overall mortality | ||||||
| Crude | 1 (reference) | 3.30 (1.27–8.57) | 0.014 | 1 (reference) | 1.20 (0.46–3.10) | 0.711 |
| Adjusteda | 1 (reference) | 3.87 (1.10–13.61) | 0.035 | 1 (reference) | 2.03 (0.57–7.21) | 0.276 |
| 5-year disease-specific mortality | ||||||
| Crude | 1 (reference) | 5.64 (1.62–19.73) | 0.007 | 1 (reference) | 1.55 (0.57–4.21) | 0.388 |
| Adjusteda | 1 (reference) | 6.17 (1.19–31.90) | 0.030 | 1 (reference) | 3.23 (0.78–13.37) | 0.105 |
Follow-up ended on December 31, 2017. In patients operated in 2018, follow-up ended 30 days after surgery.
aAdjustment for age (continuous), sex (female/male), Charlson Comorbidity Index (0–1, 2 or higher), stage (1, 2 or higher), cirrhosis (no/yes), year of surgery/diagnosis (1983–2005 and 2006–2018), Child–Pugh index (A, B or C) and tumour grade (1–2 and 3).