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. 2020 Jul 7;47(5):305–308. doi: 10.1053/j.seminoncol.2020.07.002

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© 2020 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 2 — Potential protective antioxidant and anti-inflammatory effects of RRx-001 on SARS-CoV-2-induced lung injury. RRx-001 may provide support for patients with ALI/ARDS and related complications. It is associated with Nrf2/antioxidant response element signaling, which effectively reduces ROS levels, which are elevated in acute lung injury (ALI), and inhibition of the proinflammatory NF-κB pathway. ARDS = acute respiratory distress syndrome.