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. 2020 Jul 1;8:553. doi: 10.3389/fcell.2020.00553

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Copyright © 2020 Sun, Yu, Li and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BRG1 and CHD4 are closely-linked with ADNP-regulated chromatin accessibility. (A) Heatmap showing ADNP, BRG1 and CHD4 ChIP-seq enrichment around ± 2 kb ADNP-dependent and ADNP-independent ATAC-seq peak centers. (B) A Venn diagram analysis of BRG1-, CHD4- and ADNP-dependent ATAC hypersensitive peaks. (C) A snapshot showing overlapping BRG1-, CHD4- and ADNP-dependent ATAC-seq peaks at the Tmem125 locus. (D) Correlation analysis of loci with overlapping ATAC-seq signals revealed a high degree of co-localization of BRG1-, CHD4- and ADNP-dependent ATAC hypersensitive peaks. (E) A heat map of ATAC-seq signal around the ATAC peak center, in the presence or absence of each factor. Sites are ranked by the increase of ATAC-seq signal following loss of ADNP activity.