Figure 6.

Ablation of Rictor reduces Akt signaling activation. Western blot analysis of the mTORC2/Akt signaling cascade in livers of Rictor^fl/fl and Rictor^LKO mice under 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet. Glyceraldehyde-3-phosphate dehydrogenase (Gapdh) was used as loading control. 4Ebp1, eukaryotic translation initiation factor 4E-binding protein 1; CK19, cytokeratin 19; FoxO1, forkhead box O1; KO, knockout; mSin1, mitogen-activated protein kinase associated protein 1; mTOR, mammalian target of rapamycin; p-, phosphorylated; Pras40, proline-rich AKT substrate of 40 kDa; Rictor, rapamycin-insensitive companion of mTOR; Rps6, ribosomal protein S6; Sox9, SRY (sex determining region Y)-box 9; t-, total.