Figure 3.

Interaction of Gnaq and Gna11 knockout mutations with Dsk1, Dsk7 and Dsk10. (a–e) Representative samples of tail dermis from 3-week-old mice. (f) The average pixel intensity of each genotype was normalized to the average of the Dsk heterozygotes in each cross, which was set at 100. Genotypes, shown below tails in a–e and to the right of the histogram in f, are as follows: 1, Gnaq^Dsk1/+; 2, Gnaq^Dsk1/KO; 3, +/+; 4, Gnaq^KO/+; 5, Gnaq^Dsk10/+; 6, Gnaq^Dsk10/KO; 7, +/+; 8, Gnaq^KO/+; 9, Gna11^Dsk7/+; 10, Gna11^Dsk7/+ Gnaq^KO/+; 11, Gna11^Dsk7/KO Gnaq^KO/+; 12, Gna11^Dsk7/+ Gnaq^KO/KO; 13, +/+; 14, Gnaq^Dsk1/+; 15, Gnaq^Dsk1/+ Gna11^KO/+; 16, Gnaq^Dsk1/+ Gna11^KO/KO; 17,18, Gna11^Dsk7/+; 19,20, Gna11^Dsk7/KO. Lof, loss-of-function (knockout alleles); Gof, gain-of-function (Dsk alleles).