Table 1.

Chaperone network genes likely involved in the arms race between TBSV and its hosts.

Pro-viral effect
Gene	Function	Pro-viral function	Homologs
SSA1/2	Hsp70, constitutive	Activation of p92 RdRp	Hsp70-1/2
SSA3/4	Hsp70, heat-shock induced	Partially redundant with Ssa1/2
SSB1	Hsp70, ribosome associated	Binds to p92
HSC82	Hsp90, constitutive	Binds to p92	Hsp90
HSP104	Hsp104, disaggregase	Binds to p92	Hsp104

Antiviral effect
Gene	Function	Antiviral function	Homologs
CPR7	TPR domain, cyclophilin	Inhibition of VRC assembly	Cyp40
CNS1	TPR domain, co-chaperone	Inhibition of VRC assembly	TTC4 oncogene
STI1	TPR1 domain, co-chaperone	Inhibition of CIRV VRC assembly	Hop
CPR6	TPR domain, cyclophilin	Weak inhibitor of VRC assembly	Cyp40

Undefined effect/function
Gene	Function	Viral target	Homologs
SGT2	TPR domain, co-chaperone	Interacts with p33	hSGT-like
JJJ1	Co-chaperone	Interacts with p33/p92/(+)RNA over-expression stimulatory	Hsp40
JJJ3	Co-chaperone	Interacts with p33	Hsp40
YDJ1	Co-chaperone	Over-expression inhibitory	Hsp40
CDC37	Co-chaperone	ts-mutant, reduced viral replication
SEC17	TPR domain	Inhibition of TBSV replication in vitro

Genes shown in bold face are characterized in details in TBSV replication.