Table 2.

DEAD-box helicases and RNA chaperones likely involved in the arms race between TBSV and its hosts.

Pro-viral effect
Gene	Function	Pro-viral function	Homologs
DED1	DEAD-box helicase	(−) and (+)-strand synthesis	DDX3/AtRH20
DBP2	DEAD-box helicase	(+)-strand synthesis	p68/AtRH20
AtRH2	DEAD-box helicase	(+)-strand synthesis	eIF4AIII/ScFAL1
AtRH5	DEAD-box helicase	(+)-strand synthesis	DDX5/ScDBP3
TEF1/2	Translation elongation factor	(−)-strand synthesis, p92 binding	eEF1A
TEF4	Translation elongation factor	(−)-strand synthesis	eEF1Bγ
TDH2/3	GAPDH, glycolysis	(+)-strand synthesis	GAPDH/AtGAPC

Antiviral effect
Gene	Function	Antiviral function	Homologs
AtRH30	DEAD-box helicase	Inhibition of (+)RNA recruitment	DDX17
NSP1	Ribosomal RNA maturation	Inhibition of (+)RNA recruitment	Nucleolin

Undefined effect/function
Gene	Function	Viral target	Homologs
TIF1	Translation initiation factor eIF4A DEAD-box helicase	Interacts with p33	eIF4A
TIF11	Translation initiation factor eIF1A DEAD-box helicase	Interacts with p33/p92	eIF1A
PBP2	heterogeneous nuclear RNP K protein	Over-expression is stimulatory
HAS1	ATP-dependent RNA helicase	Over-expression is inhibitory

Genes shown in bold face are characterized in details in TBSV replication.