Table 1.
Baseline characteristics of coronavirus disease 2019 (COVID-19) and M. pneumoniae co-infection patients.
| Characteristics | COVID-19 mono-infection patients (n = 88) | COVID-19 patients co-infection with M. pneumoniae (n = 22) | p |
|---|---|---|---|
| Baseline | |||
| Age (years) | 57.00 (46.50–65.00) | 56.50 (52.50–66.50) | 0.726 |
| Male | 45 (51.1) | 11 (50.0) | 1.000 |
| Time from illness onset to hospital admission (days) | 10.50 (7.00–20.00) | 14.50 (5.50–20.00) | 0.666 |
| Comorbidities | |||
| Diabetes | 20 (22.7) | 5 (22.7) | 1.000 |
| Hyperlipemia | 3 (3.4) | 1 (4.5) | 1.000 |
| Hypertension | 16 (18.2) | 4 (18.2) | 1.000 |
| Chronic heart failure | 2 (2.3) | 1 (4.5) | 1.000 |
| Liver cirrhosis | 2 (2.3) | 2 (9.1) | 0.373 |
| Anemia | 6 (6.8) | 2 (9.1) | 1.000 |
| Chronic kidney diseases | 1 (1.1) | 1 (4.5) | 0.858 |
| Rheumatoid arthritis | 0 (0.0) | 2 (9.1) | 0.05 |
| Cerebrovascular disease | 1 (1.1) | 1 (4.5) | 0.858 |
| Myasthenia Gravis | 1 (1.1) | 1 (4.5) | 0.858 |
| Deep venous thrombosis | 0 (0.0) | 1 (4.5) | 0.451 |
| COPD | 6 (6.8) | 1 (4.5) | 1.000 |
| Symptoms | |||
| Fever | 55 (62.5) | 10 (45.5) | 0.226 |
| Cough | 27 (30.7) | 4 (18.2) | 0.368 |
| Dyspnea | 7 (8.0) | 2 (9.1) | 1.000 |
| Fatigue | 6 (6.8) | 4 (18.2) | 0.214 |
| Diarrhea | 2 (2.3) | 2 (9.1) | 0.373 |
| Chestpain | 1 (1.1) | 0 (0.0) | 1.000 |
| Dizzy | 0 (0.0) | 1 (4.5) | 0.451 |
| other | 11 (12.5) | 4 (18.2) | 0.728 |
| Signs | |||
| Respiratory rate | 36.70 (36.50–37.02) | 36.50 (36.30–36.98) | 0.096 |
| Heart rate | 86.00 (79.75–97.25) | 94.00 (79.25–98.50) | 0.437 |
| Systolic pressure (mmHg) | 20.00 (18.00–20.00) | 19.50 (18.00–20.00) | 0.273 |
| Diastolic pressure (mmHg) | 130.00 (120.00–139.25) | 127.00 (116.00–143.25) | 0.672 |
| Peripheral oxygen saturation (%) | 80.00 (73.50–87.00) | 82.50 (72.75–88.50) | 0.624 |
| Laboratory tests | |||
| White blood cell count (× 109/L) | 5.63 (4.90–7.08) | 5.81 (5.13–6.84) | 0.627 |
| Neutrophil count (× 109/L) | 3.55 (2.91–5.19) | 3.35 (2.64–5.43) | 0.725 |
| Lymphocyte count (× 109/L) | 1.35 (0.91–1.73) | 1.63 (1.20–2.04) | 0.167 |
| Monocyte count (× 109/L) | 0.39 (0.31–0.51) | 0.38 (0.33–0.56) | 0.257 |
| Hemoglobin (g/L) | 131.00 (119.00–142.00) | 123.00 (118.50–130.50) | 0.087 |
| Platelet count (× 109/L) | 204.00 (165.75–258.25) | 187.50 (144.00–250.25) | 0.269 |
| Albumin (g/L) | 39.90 (36.90–43.85) | 41.65 (36.12–43.05) | 0.858 |
| Alanine aminotransferase (ALT) (U/L) | 22.70 (15.10–33.15) | 23.15 (13.98–33.23) | 0.949 |
| Aspartate aminotransferase (AST) (U/L) | 19.60 (15.00–26.25) | 19.30 (14.53–23.70) | 0.834 |
| Direct Bilirubin (μmol/L) | 3.28 ± 2.15 | 19.19 ± 72.26 | 0.039 |
| Indirect Bilirubin (μmol/L) | 8.03 ± 4.07 | 14.67 ± 28.72 | 0.037 |
| Creatine (μmol/L) | 68.15 (55.82–88.95) | 56.70 (50.48–72.72) | 0.057 |
| Urea (mmol/L) | 4.50 (3.83–5.60) | 4.21 (3.34–4.54) | 0.151 |
| Creatine kinase (U/L) | 70.50 (49.75–115.75) | 66.00 (48.75–78.75) | 0.279 |
| Creatine kinase -MB (U/L) | 6.00 (5.00–9.00) | 7.15 (5.00–11.40) | 0.324 |
| Troponin (ng/mL) | 0.00 (0.00–0.01) | 0.01 (0.00–0.03) | 0.12 |
| Brain Natriuretic Peptid (pg/mL) | 32.50 (14.88–85.75) | 58.50 (20.75–126.85) | 0.245 |
| Lactate dehydrogenase (U/L) | 156.00 (138.00–194.75) | 177.00 (141.00–208.25) | 0.52 |
| Blood glucose (mmol/L) | 5.29 (4.70–6.99) | 5.55 (5.12–7.25) | 0.358 |
| Sodium (mmol/L) | 140.00 (137.57–142.00) | 139.50 (138.00–140.90) | 0.386 |
| Potassium (mmol/L) | 4.21 (3.97–4.50) | 4.16 (4.01–4.39) | 0.572 |
| Calcium (mmol/L) | 2.29 (2.19–2.45) | 2.38 (2.28–2.45) | 0.188 |
| Chloride (mmol/L) | 103.30 (102.02–106.40) | 104.20 (101.17–106.48) | 0.934 |
| Phosphorus (mmol/L) | 1.09 (0.93–1.22) | 1.11 (0.98–1.22) | 0.731 |
| Prothrombin Time (s) | 13.34 ± 5.40 | 11.60 ± 0.84 | 0.004 |
| International Normalized Ratio | 1.16 ± 0.50 | 1.00 ± 0.08 | 0.005 |
| Prothrombin Activity (%) | 89.78 ± 30.65 | 104.90 ± 20.14 | 0.006 |
| Activated Partial Thromboplastin Time (s) | 31.07 ± 8.88 | 28.53 ± 5.15 | 0.082 |
| Thrombin Time (s) | 16.95 ± 1.79 | 16.88 ± 1.54 | 0.86 |
| Fibrinogen (g/L) | 2.52 (2.17–3.05) | 2.37 (2.09–2.60) | 0.121 |
| D-dimer (ug/mL) | 0.45 (0.25–1.02) | 0.72 (0.44–1.61) | 0.062 |
| Interleukin-6 (pg/mL) | 4.49 (2.26–12.34) | 2.90 (2.08–5.89) | 0.138 |
| Procalcitonin (ng/ml) | 0.05 (0.04–0.08) | 0.05 (0.03–0.07) | 0.382 |
| C Reactive Protein (mg/dl) | 0.36 (0.12–2.63) | 0.24 (0.10–2.08) | 0.452 |