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. 2020 Jul 1;11:1238. doi: 10.3389/fimmu.2020.01238

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Copyright © 2020 Navegantes-Lima, Monteiro, de França Gaspar, de Brito Oliveira, de Oliveira, Reis, de Souza Gomes, Rodrigues, Stutz, Sovrani, Peres, Romão and Monteiro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of A. brasiliensis aqueous extract on survival rate (%), body weight, hematological[[Inline Image]] parameters, bacterial burden, and systemic inflammatory response in septic mice. (A) Survival of septic animals pretreated with Ab (135 mg/kg), CEF (20 mg/Kg), or saline (0.9%). (B) Body weight during 12 days. (C) Total leukocyte counts 24 h post CLP. (D) Monocyte counts 24 h post CLP. (E) Neutrophil counts 24 h post CLP. (F) Platelet counts 24 h post CLP. (G) Bacterial load in the blood 12 and 24 h post CLP. (H) NO levels 12 h and 24 h after CLP. (I) IL-1β and (J) TNF-α levels in serum of septic animals 24 h post CLP. Data presented as mean ± SD. (*p < 0.05 Saline-CLP or Ab-CLP vs. Sham; #p < 0.05 Ab-CLP vs. Saline-CLP).