表2. 免疫球蛋白重链可变区(IGHV)突变患者与未突变患者临床特征比较.
IGHV突变组(30例) | IGHV未突变组(10例) | P值 | |
血常规 | |||
WBC[×109/L,M(范围)] | 16.79(2.42~126.82) | 19.12(2.28~61.68) | 0.749 |
HGB[g/L,M(范围)] | 107(53~151) | 102(85~142) | 0.753 |
PLT[×109/L,M(范围)] | 92(34~569) | 125(38~440) | 0.368 |
ALC[×109/L,M(范围)] | 10.54(0.44~123.00) | 7.08(0.28~45.50) | 0.480 |
肿瘤负荷 | |||
LDH[U/L,M(范围)] | 173(107~515) | 225(118~400) | 0.965 |
β2微球蛋白[mg/L,M(范围)] | 4.18(1.54~11.90) | 3.50(2.41~9.69) | 0.971 |
免疫球蛋白 | |||
IgG[g/L,M(范围)] | 10.70(5.28~23.50) | 12.90(7.71~23.50) | 0.038 |
IgA[g/L,M(范围)] | 1.06(0.21~3.13) | 1.66(0.81~2.93) | 0.040 |
IgM[g/L,M(范围)] | 0.90(0.18~31.10) | 1.22(0.35~16.50) | 0.659 |
细胞遗传学 | |||
RB-1缺失[例(%)] | 0 | 0 | - |
17P缺失[例(%)] | 0 | 2(6.67) | 0.060 |
ATM缺失[例(%)] | 0 | 0 | - |
IgH易位[例(%)] | 5(16.67) | 1(3.33) | 1.000 |
注:ALC:淋巴细胞绝对计数;-:无法统计