表2. 重组人-鼠嵌合抗CD20单抗IBI301Ⅰ期剂量递增试验给药后不同时间受试者CD19+、CD20+细胞比例.
例号 | IBI301剂量 | CD19+细胞比例(%) |
CD20+细胞比例(%) |
||||||||||
0 da | 3 d | 8 d | 29 d | 57 d | 85 d | 0 da | 3 d | 8 d | 29 d | 57 d | 85 d | ||
1 | 125 mg/m2 | 0.6 | 0.1 | 0 | 0 | 0 | 0 | 0.6 | 0 | 0 | 0 | 0 | 0 |
2 | 125 mg/m2 | 18.3 | 0.8 | 0.5 | 0.4 | 11.2 | 16.2 | 18.3 | 0 | 0 | 0.4 | 11.2 | 16.2 |
3 | 125 mg/m2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
4 | 375 mg/m2 | 4.9 | 0.2 | 0 | 0 | 0 | 0 | 4.9 | 0 | 0 | 0 | 0 | 0 |
5 | 375 mg/m2 | 1.4 | 0.2 | 0 | 0 | 0 | 0 | 1.4 | 0 | 0 | 0 | 0 | 0 |
6 | 375 mg/m2 | 0.1 | 0 | 0 | 0 | 0 | 0 | 0.1 | 0 | 0 | 0 | 0 | 0 |
7 | 500 mg/m2 | 0.5 | 0 | 0 | 0 | 0 | 0.1 | 0.5 | 0 | 0 | 0 | 0 | 0 |
8 | 500 mg/m2 | 11.3 | 0.4 | 0 | 0.1 | 0 | 0 | 11.2 | 0 | 0 | 0.1 | 0 | 0 |
9 | 500 mg/m2 | 11.2 | 1.5 | 0.4 | 0 | 0.2 | 0.3 | 11.2 | 0 | 0 | 0 | 0 | 0 |
注:a:治疗前