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. 2018 Jul;39(7):552–557. [Article in Chinese] doi: 10.3760/cma.j.issn.0253-2727.2018.07.005

表1. 接受allo-HSCT的206例AML患者初诊时突变基因的检出情况.

基因突变 例数(%)
FLT3-ITD 26(12.6)
duCEBPA 20(9.7)
DNMT3A R882+FLT3-ITD+NPM1 14(6.8)
DNMT3A R882 14(6.8)
siCEBPA 9(4.4)
FLT3-ITD+NPM1 7(3.4)
FLT3-ITD+duCEBPA 4(1.9)
FLT3-TKD 4(1.9)
DNMT3A R882+FLT3-ITD 4(1.9)
c-kit 3(1.5)
NPM1 3(1.5)
duCEBPA+c-kit 2(1.0)
DNMT3A R882+NPM1 2(1.0)
siCEBPA+NPM1 2(1.0)
DNMT3A R882+NPM1+ FLT3-TKD 2(1.0)
FLT3-ITD+siCEBPA 1(0.5)
duCEBPA+ FLT3-TKD 1(0.5)
NPM1+ c-kit 1(0.5)
DNMT3A R882+ FLT3-TKD 1(0.5)
FLT3-TKD+ NPM1 1(0.5)
DNMT3A R882+NPM1+siCEBPA 1(0.5)
DNMT3A R882+FLT3-ITD+NMP1+c-kit 1(0.5)
DNMT3AR882+NPM1+siCEBPA+FLT3-TKD 1(0.5)
阴性组 82(39.8)

注:duCEBPA:双突变CEBPA;siCEBPA:单突变CEBPA;阴性组:未检出任何已知突变