Figure 3.

The SEI values of doxorubicin on DFs and ADSCs at their different passages when compared to HepG2 and MCF-7 cells. (A) SEI values were significant increased as the passages of DFs increased from the 3rd to 6th, 9th and 12 passages- in the HepG2 model; however, the SEI values changed for ADSCs from the 3rd through 12th passage in that model. (B) Similarly, the SEI values also strongly increased when using DFs as the normal cell control, while the SEI values were nonsignificantly changed when ADSCs were used as the normal cell control in the MCF-7 model.

Abbreviations: ADSCs, adipose-derived stem cells; DFs, dermal fibroblasts; SEI, side effect index.