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. 2020 Jul 6;8(1):e001516. doi: 10.1136/bmjdrc-2020-001516

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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(A) Plasma NfL differences across groups (*p<0.05, **p<0.005). Scatter plots illustrating a subset of significant associations between NfL levels and (B) Clarke scores in patients with T1D, (C) frontal lobe GMV within the T1D-IAH group, and (D) number of severe or moderate hypoglycemic episodes within the T1D-IAH group. GMV, gray matter volumes; HC, healthy controls; IAH, impaired awareness of hypoglycemia; NAH, normal awareness of hypoglycemia; NfL, neurofilament light chain; T1D, type-1 diabetes.