Table 3.

Susceptibility of Invasive Streptococcus pneumoniae to Routine Clinical Antibiotics

Antibiotics	%R	%I	%S	MIC50	MIC90	Range	%R (N)
							PRSP (93)	PISP (38)	PSSP (33)	Age <18 (140)	Age ≥18 (24)	Children and Maternal (109)	General (55)
Penicillin V oral	56.7	23.2	20.1	2	4	0.004–8	100	0.0	0.0	62.9	20.8	61.5	47.3
Penicillin G meningitis	79.9	0.0	20.1	2	4	0.004–8	100	100	0.0	83.6	58.3	81.7	76.4
Penicillin G non-meningitis	1.2	18.9	79.9	2	4	0.004–8	2.2	0.0	0.0	1.4	0.0	0.9	1.8
Amoxicillin/Clavulanic acid	20.7	13.4	65.9	1	8	0.008–32	36.6	0.0	0.0	22.9	8.3	22.9	16.4
Cefaclor	78.0	9.1	12.8	256	256	0.016–256	100	92.1	0.0	82.1	54.2	79.8	74.5
Cefuroxime	62.8	9.8	27.4	4	16	0.016–128	97.8	31.6	0.0	67.9	33.3	65.1	58.2
Ceftriaxone non-meningitis	9.1	4.3	86.6	0.5	2	0.016–8	15.1	2.6	0.0	10.0	4.2	9.2	9.1
Ceftriaxone meningitis	13.4	29.3	57.3	0.5	2	0.016–8	22.6	2.6	0.0	15.0	4.2	12.8	14.5
Vancomycin	0.0	0.0	100	0.25	0.25	0.016–0.5	0.0	0.0	0.0	0.0	0.0	0	0.0
Erythromycin	98.2	0.0	1.8	128	256	0.016–256	100	97.4	93.9	97.9	100	98.2	98.2
Azithromycin	97.6	0.6	1.8	256	256	0.016–256	100	94.7	93.9	97.1	100	98.2	96.4
Clarithromycin	98.2	0.0	1.8	256	256	0.25–256	100	97.4	93.9	97.9	100	98.2	98.2
Tetracycline	94.5	1.2	4.2	32	64	0.016–128	95.7	94.7	90.9	94.3	95.8	95.4	92.7
Levofloxacin	1.2	0.0	98.8	1	1	0.016–16	1.1	2.6	0.0	0.0	8.3	0	3.6
Moxifloxacin	0.0	1.2	98.8	0.125	0.125	0.016–2	0.0	0.0	0.0	0.0	0.0	0	0.0
Trimethoprim/Sulfamethoxazole	59.8	7.3	32.9	4	16	0.016–256	73.1	52.6	30.3	61.4	50.0	58.7	61.8
Chloramphenicol	7.3	0.0	92.7	4	4	0.016–16	5.4	2.6	18.2	4.3	25.0	4.6	12.7
Clindamycin	96.3	0.6	3.0	256	256	0.016–256	100	92.1	90.9	96.4	95.8	97.2	94.5