Table 1.
Oncogenic or Suppressive Roles of lncRNA SNHG5 in Cancers
| Human Cancers | Roles | Assessed Cell Lines | Targets | Related Biological Activities | Reference |
|---|---|---|---|---|---|
| Glioma | Oncogene | U251, LN229 | miR-205-5p/ZEB2 axis | ↑proliferation | 24 |
| Oncogene | U251, U87 | miR-205/E2F3 axis | ↑migration, ↑invasion, ↑xenograft growth | 9 | |
| Oncogene | U251, U87 | Wnt/β-catenin signaling | ↑proliferation, ↑invasion, ↓apoptosis | 20 | |
| Glioblastoma (GBM) | Oncogene | U87, U251 | p38/MAPK signaling | ↑proliferation, ↓apoptosis | 11 |
| Nasopharyngeal carcinoma (NPC) | Oncogene | NP69, C666–1 | miR-1179/HMGB3 axis | ↑proliferation, ↑migration, ↑invasion, ↓apoptosis | 18 |
| Breast cancer (BRCA) | Oncogene | T47D, MDA-MB-231 | miR-154-5p/PCNA axis | ↑proliferation, ↑cell-cycle, ↓apoptosis, ↑xenograft growth | 19 |
| Hepatocellular carcinoma (HCC) | Oncogene | HepG2, MHCC-97L | miR-26a-5p/GSK3β axis | ↑proliferation, ↑invasion, ↑migration, ↑cell-cycle, ↓apoptosis, ↑xenograft growth | 30 |
| Oncogene | Hep3B, Huh7 | miR-363-3p/RNF38 axis | ↑proliferation, ↑invasion, ↑migration, ↓apoptosis | 31 | |
| Gastric cancer (GC) | Suppressor | SGC7901, MKN45 | miR-20a | ↑apoptosis, ↑autophagy | 32 |
| Suppressor | SGC-7901, MGC-803 | miR-32/KLF4 axis | ↓proliferation, ↓migration | 33 | |
| Suppressor | SGC-7901, MGC-803 | MTA2 | ↓proliferation, ↓migration, ↓invasion, ↓xenograft growth | 10 | |
| Oncogene | BGC823, SGC7901 | / | ↑proliferation, ↓apoptosis | 34 | |
| Colorectal cancer (CRC) | Oncogene | LoVo | miR-132-3p/CERB5 axis | ↑proliferation, ↑migration, ↓apoptosis, ↑xenograft growth | 16 |
| Oncogene | HCT-116, CACO-2, DLD-1 | SPATS2 | ↑cell-cycle, ↓apoptosis, ↑xenograft growth | 21 | |
| Renal cell carcinoma (RCC) | Oncogene | ACHN, 786-O | miR-205-5p/ZEB1 axis | ↑proliferation, ↑migration, ↑invasion, ↑EMT process, ↑xenograft growth | 35 |
| Oncogene | 786-O | miR-363-3p/Twist1 axis | ↑invasion, ↓apoptosis | 36 | |
| Bladder cancer (BC) | Oncogene | UMUC3, 5637 | p27 | ↑proliferation, ↑cell cycle progression, ↑EMT process, ↓apoptosis | 23 |
| Endometrial cancer (EC) | Suppressor | KLE, HEC-1-B | miR-25-3p/BTG2 axis | ↓proliferation, ↓migration, ↓invasion | 12 |
| Acute myeloid leukemia (AML) | Oncogene | HL60 | miR-32/DNAJB9 axis | ↑proliferation | 13 |
| Oncogene | HL-60, KG-1a | miR-489-3p/SOX4 axis | ↑proliferation, ↓apoptosis, ↑xenograft growth | 38 | |
| Chronic myeloid leukemia (CML) | Oncogene | K562 | DR4 | ↑proliferation, ↓apoptosis | 22 |
| Oncogene | K562 | miR-205-5p/ABCC2 axis | ↑proliferation | 14 | |
| Melanoma (MM) | Oncogene | A375, A2508 | miR-26a-5p/TRPC3 axis | ↑proliferation, ↑invasion, ↓apoptosis | 15 |
| Osteosarcoma (OS) | Oncogene | 143B, U2OS | miR-212-3p/SGK3 axis | ↑proliferation, ↑migration, ↑invasion, ↓apoptosis | 40 |
| Oncogene | MG63, U2OS | miR-26a/ROCK1 axis | ↑proliferation, ↑invasion, ↑ migration, ↑cell-cycle | 17 |
Abbreviations: ZEB2, zinc finger E-box binding homeobox 2; E2F3, E2F transcription factor 3; HMGB3, high mobility group box 3; PCNA, proliferating cell nuclear antigen; GSK3β, glycogen synthase kinase 3β; RNF38, ring finger protein 38; KLF4, Kruppel like factor 4; MTA2, metastasis-associated genes protein 2; CERB5, cAMP-responsive element-binding protein 5; SPATS2, spermatogenesis associated serine rich 2; ZEB1, zinc finger E-box binding homeobox 1; EMT, epithelial-mesenchymal transition; BTG2, B-cell translocation gene 2; DNAJB9, DNAJ homolog subfamily B member 9; SOX4, sex-determining region Y-box 4; DR4, TRAIL-R1; ABCC2, ATP-binding cassette sub-family C member 2; TRPC3, transient receptor potential canonical 3; SGK3, serum glucocorticoid regulated kinase 3; ROCK1, Rho-associated protein kinase 1.