Table 2.

Clinical Implications of lncRNA SNHG5 in Cancers

Human Cancers	Numbers (Clinical Cases/Controls)	Clinical Significance	Reference
Glioma	87 glioma tissues and 81 normal brain tissues	↑pathological grade	9,20,24
Nasopharyngeal carcinoma (NPC)	64 NPC tissues and adjacent normal breast tissues	↑tumor stage, ↓overall survival	18
Breast cancer (BRCA)	30 BRCA tissues and adjacent normal breast tissues	↑tumor stage, ↑tumor size, ↓overall survival	25–28
Hepatocellular carcinoma (HCC)	79 HCC specimens and non-tumor tissues	↑tumor size, ↑HBV infection, ↑histologic grade, ↑TNM stage, ↑PVTT, ↓overall survival	30,31
Gastric cancer (GC)	13 pairs of GC tissues and non-tumor tissues	↑cisplatin resistance	32,33
	158 GC tissues and non-tumor tissues	↓CEA level, ↓TNM grade, ↓tumor embolus formation	34
Colorectal cancer (CRC)	69 couples of CRC and adjacent tissues	↑tumor stage	16,21
Renal cell carcinoma (RCC)	52 RCC tissues and adjacent normal kidney tissues	↑TNM stage, ↑tumor size, ↑lymphatic invasion, ↑distant metastasis	35,36
Bladder cancer (BC)	67 BC tissues and matched non-cancerous tissues	↑tumor range, ↑metastasis, ↑lymph nodes invasion, ↑pathological stage, ↓overall survival	23
Endometrial cancer (EC)	86 EC tissues and non-cancer tissues	↓clinical stage, ↑overall survival, ↑disease-free survival	12
Acute myeloid leukemia (AML)	101 AML patients and 53 healthy volunteers	↑FAB classification, ↑unfavorable cytogenetics, ↓overall survival	13,37,38
Chronic myeloid leukemia (CML)	40 CML patients and 20 healthy volunteers	imatinib resistance	14,22
Melanoma (MM)	50 MM tissues and matched normal tissues	↑pathological stag, ↑metastasis	15,39
Osteosarcoma (OS)	32 pairs of OS tissues and adjacent normal tissues	↑tumor size, ↑tumor grade, ↑metastasis, ↑Enneking stage, ↓overall survival	17,40

Abbreviations: HBV, hepatitis B virus; TNM, tumor-node-metastasis; PVTT, portal vein tumor thrombus; CEA, carcinoembryonic antigen.