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. 2020 Jul 3;13:6497–6509. doi: 10.2147/OTT.S256818

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© 2020 Wei et al.

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The 6-EMT gene signature may predict metastasis of TNBC in patients treated with surgery followed by adjuvant chemotherapy as shown by analysis of the ICO-UMGC-based cohort of the GEO dataset (GSE103091). (A) The distribution of the prognostic values of the 107 TNBC patients who were classified into high-risk and low-risk groups (top panel), and the corresponding distant metastasis-free survival status for each patient (bottom panel). (B) Kaplan–Meier analysis of the probability of metastasis-free survival of the patients in the ICO-UMGC-based cohort. (C) Time-dependent ROC curves for patients in the ICO-UMGC-based cohort. AUCs at 1.5, 3, and 5 years were used to evaluate the accuracy of the prognostic model.

Abbreviations: EMT, epithelial–mesenchymal transition; TNBC, triple-negative breast cancer; ROC, receiver operating characteristic; AUC, area under curve; HR, hazard ratio; NACT, neoadjuvant chemotherapy.