Demographic and clinical data of the patients included in the study

	CIS Group (n = 112)	Non-MS Group (n = 35)
Mean age (SD, range) (yr)	35.4 (7.9, 19–49)	41.7 (11.5, 20–67)
Sex, female No. (%)	70 (70.5%)	23 (65.7%)
Clinical diagnosis at the end of the study No. (%)	MS = 94 (83.9%) (including CDMS = 42 [37.5%]) CIS = 18 (16.1%)	Autoimmune disease = 13 (37.1%)Vascular disease = 8 (22.9%)Incidental findings = 1 (2.9%)Infectious disease = 1 (2.9%)Headache = 3 (8.6%)Other = 9 (25.7%)
+/− OCBs No. (not performed)	80/21 (11)	2/15 (18)
Median EDSS (range)	1.5 (0–4.5)	NA
Median WM lesion No. (range)	4 (1–31)	7 (1–31)

Note:—EDSS indicates Expanded Disability Status Scale; NA, not available.